10f-THF: 10-formyltetrahydrofolate 5mTHF: 5-methyltetrahydrofolate AICAR: P-ribosyl-5-amino-4-imidazole carboxamide CH = THF: 5-10-methenyltetrahydrofolate CH2-THF: 5-10-methylenetetrahydrofolate Cys: cysteine Cysta cystathionine DHF: dihydrofolate DMG: dimethylglycine dTMP: deoxythymidine monophosphate dUMP: deoxyuridine monophophate GAR: glycinamide ribonucleotide Glut: glutamate Glut: Cys glutamyl-cysteine Gly: glycine
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557 Recent studies have found that the expression of HIF-2 may facilitate the maintenance of a pseudohypoxic state in cells, thereby promoting the onset and progression of diseases, including renal clear cell carcinoma, 558 pancreatic cancer, 559 and breast cancer
However, DRI peptides are not substrates for renal peptidases that normally degrade filtered peptides
